高齡照護人機介面輔助研究團隊

主持人: 吳菁宜教授

研究專長：動作控制與學習、中風上肢神經復健、腦影像學分析

研究團隊成員:

吳菁宜主任、謝妤葳老師、李冠逸老師、鄭嘉雄老師、陳柏伃老師、莊宜靜老師、張雅如主任、林佩欣老師、林燕慧老師、鄭智修老師、莊麗玲老師、謝宗勳老師、詹曉龍老師

研究架構圖：

研究計畫：

目的:

針對社區老人或衰弱、退化性(如Parkinson disease)、腦血管疾病老人，建立篩檢、預測疾病發生或再發的生物行為與神經生理偵測指標，並驗證次級預防(secondary prevention)惡化、退化或再發之治療方案，建立具實證治療手法之虛擬實境與監測系統，以及推廣至社區及居家之健康促進方案。

方法:

(一) 利用發展出之嗅覺、動作知覺及平衡測試儀，針對社區或退化性老人進行篩檢，建立篩檢動作及感覺障礙與神經損傷之系統。

(二) 針對生理、認知退化或障礙的長者，進行認知與運動功能檢測，並設計認知與運動相關之訓練組合，驗證該訓練對促進體能、生理、智能狀況的成效

(三) 針對腦血管疾病老人，根據目前新興的非侵入性神經刺激技術，結合行為治療（包含機器輔助治療）研發複合療法，改善生理認知功能，同時結合工程科技，建立即時監測及預警系統。

(四) 依據上述驗證之訓練方案，針對老化族群建立虛擬實境與監控系統，提供遠距離醫療服務及居家訓練。

相關研究主題：

1.老化對大腦感覺皮質抑制功能之影響：腦造影與行為學研究

2.初期中樞神經退化疾患其運動覺及嗅覺功能變化

3.疲勞之中樞與周邊臨床指標與虛擬實境抗疲勞訓練模式之建立-應用於帕金森氏病患者

4.虛擬實境雙重任務檢測與訓練平台設計-應用於帕金森氏病患者

5.利用感壓鞋墊建立衰弱老化相關監測參數

6.機器輔助訓練對中風患者於動作控制/表現、生活功能與生理反應之成效

7.有氧運動合併認知訓練對中風患者之認知功能、生理指標、生活功能與生活品質之療效

8.高齡者行動輔具操控虛擬訓練

9.衰弱、失智、行動不便失能者之健康促進方案、虛擬實境介入系統研發(體感Kinect運動介入)，以體感偵測老年人之體適能與平衡能力

10.社區居住老人之不同模式運動介入方案的成效比較

跨國際研究合作：

1.社區中風患者自我效能及健康相關參數研究 (合作單位：加州州立大學多明格斯山分校職能治療系黃妍華教授)

2.腦神經律動與腦功能研究 (合作單位：加拿大蒙特婁神經醫學中心)

主要成果:

Chuang, I-C., Lin, K-C., Wu, C-Y.^*, Hsien, Y-W., Liu, C-T., Chen, C-L. (2017 Accepted). Using rasch analysis to validate the motor activity log and the lower-functioning motor activity log in patients with stroke. Physical Therapy.

Chen, H-L., Lin, K-C., Hsieh, Y-W., Wu, C-Y. ^*, Liing, R-J., Chen, C-L. (2017 Accepted). A study of predictive validity, responsiveness, and mnimally clinically important difference of arm accelerometer in real-world activity of patients with chronic stroke. Clinical Rehabilitaion.

Cheng C-H.*, Tsai S-Y., Liu C-Y., Niddam D-M. (2017 Accepted) Automatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study. Scientific Reports.

Cheng C-H.*, Sun H-H., Weng J-Q., Tseng Y-J. (2017 Accepted) Differential motor cortex excitability during observation of normal and abnormal goal-directed movement patterns. Neuroscience Research.

Li, K-Y. *, Wu, Y-H., & Chen, R-S. (2017). Interrater reliability of clinically performed manual arm position and motion matching test. Neuropsychiatry, 7(4), 290-296.

Li, K-Y. *, Chu, P-Y., & Pickett, A-K. (2017). The Effect of Dopaminergic medication on joint kinematics during haptic movements in individuals with Parkinson’s Disease. Behavioral Neurology, Article ID 2358386.

Hsieh, Y-W., Wu, C-Y., Wang, W-E., Lin, K-C., Chang, K-C., Chen, C-C., & Liu, C-T. (2017). Bilateral robotic priming before task-oriented approach in subacute stroke rehabilitation: A pilot randomized controlled trial. Clinical Rehabilitation, 31(2), 225-233.

Ma, H-Y., Lin, K-C., Hsieh, F-H., Chen, C-L., Tang, S F., & Wu, C-Y. (2017) Kinematic manifestation of arm-trunk performance during symmetric bilateral reaching after stroke: Within vs. beyond arm’s length. American Journal of Physical Medicine & Rehabilitation, 96(3), 146-151.

Hsieh,Y-W., Liing, R-J., Lin, K-C., Wu, C-Y., Liou, T-H., Lin, J-C., & Hung, J-W. (2016) Sequencing bilateral robot-assisted arm therapy and constraint-induced therapy improves reach to press and trunk kinematics in patients with stroke. Journal of NeuroEngineering and Rehabilitation, 13: 31,1-9.

Wu, C-Y., Chuang, I-C., Ma, H-I., Lin, K-C., & Chen, C-L. (2016). Validity and responsiveness of the revised nottingham sensation assessment for outcome evaluation in stroke rehabilitation. American Journal of Occupational Therapy, 70(2), 7002290040p1-8.

Hung, C-S., Hsieh, Y-W., Wu, C-Y., Lin, K-C., Lin, Y-T., & Chen, C-L. (2016). The effects of combination of robot-assisted therapy with task-specific or impairment-oriented training on motor function and quality of life in chronic stroke. American Academy of Physical Medicine and Rehabilitation, 1-8.

Cheng, C-H., Chan, P-Y., Hsieh, Y-W., & Chen. K-F. (2016) A meta-analysis of mismatch negativity in children with attention deficit-hyperactivity disorders. Neuroscience Letters, 612, 132-137.

Chan, P-Y., Cheng, C-H., Jhu, Y-J., Chen, C-L., & von Leupoldt, A. (2016) Being Anxious, Thinking Positively: The Effect of Emotional Context on Respiratory Sensory Gating. Frontiers in Physiology, 7: 19.

Cheng, C-H., Tseng, Y-J., Chen, R-S., & Lin, Y-Y. (2016) Reduced functional connectivity of somatosensory network in writer's cramp patients. Brain and Behavior, 6(3), e00433.

Cheng, C-H., Chan, P-Y., Niddam, D-M., Tsai, S-Y., Hsu, S-C., & Liu, C-Y. (2016) Sensory gating, inhibition control and gamma oscillations in the human somatosensory cortex. Scientific Reports, 6: 20437.

Huang, H-H. (2016) Commentary on "Modified Ride-on Car Use by Children with Complex Medical Needs". Pediatric Physical Therapy, 28(1): 108.

Lin, P-S., Hsieh, C-C., Cheng, H-S., Tseng, T-J., & Su, S-C. (2016) Association between Physical Fitness and Successful Aging in Taiwanese Older Adults. PloS One, 11(3): e0150389.

Liang, P-J., & Lin, P-S. (2016) Reliability and Validity of the Stroke Impact Scale 3.0 in Taiwanese Stroke Patients. Formosan Journal of Physical Therapy, 41(1), 28-36.

Lin, Y-C., Tsai, L-C., Cheng, H-Y., Lin, Y-H., & Cheng, C-H. (2016) Postural steadiness after prolonged standing on different sloped surface in young health adults. Biomedical Engineering: Applications, Basis and Communications, 28, 1650007.

Cheng, C-H., Chien, A., Hsu, W-L., Chen, C-P., & Cheng, H-Y. (2016) Investigation of the differential contributions of superficial and deep muscles on cervical spinal loads with changing head postures. PLoS One, 11(3), e0150608.

Cheng, C-H., Chien, A., Hsu W-L., Lai, D-M., Wang, S-F., &Wang, J-L. (2016) Identification of head control deficits following anterior cervical discectomy and fusion in patients with cervical spondylotic myelopathy. European Spine Journal, 25(6), 1855-1860.

Chen, C-C., Chuang, Y-F., Huang, A-C., Chen, C-K., & Chang, Y-J. (2016) The antalgic effects of non-invasive physical modalities on central post-stroke pain: a systematic review. Journal of Physical Therapy Science, 28(4), 1368-1373.

Lee, Y-Y., Hsieh, Y-W., Wu, C-Y., Lin, K-C., & Chen, C-K. (2015). Proximal Fugl-Meyer assessment scores predict clinically important upper limb improvement after 3 stroke rehabilitative interventions. Archives of Physical Medicine and Rehabilitation, 96, 2137-2144.

Chen, P-Y., Lin, K-C., Liing, R-J., Wu, C-Y., Chen, C-L., & Chang, K-C. (2015) Validity, responsiveness, and minimal clinically important difference of EQ-5D-5L in stroke patients undergoing rehabilitation. Quality of Life Research,. 25(6), 1585-1596.

Lee, Y-Y., Lin, K-C., Cheng, H-J., Wu, C-Y., Hsieh, Y-W., & Chen, C-K. (2015). Effects of combining robot-assisted therapy with neuromuscular electrical stimulation on motor impairment, motor and daily function, and quality of life in patients with chronic stroke: A double-blinded randomized controlled trial. Journal of NeuroEngineering and Rehabilitation, 12: 96, 1-10.

Fan, Y-T., Wu, C-Y., Liu, H-L., Lin, K-C., Wai, Y-Y., & Chen, Y-L. (2015). Neuroplastic changes in resting-state functional connectivity after stroke rehabilitation. Frontiers in Human Neuroscience, 9: 546, 1-12.

Fan, Y-T., Lin, K-C., Liu, H-L., Chen, Y-L., & Wu, C-Y. (2015). Changes in structural integrity are correlated with motor and functional recovery after post-stroke rehabilitation. Restorative Neurology and Neuroscience, 33(6), 835-844.

Wu, C-Y., & Chang, K-C. (2015). Constraint-induced movement therapy translated into practice. [Peer commentary on the paper “Efficacy of home-based Constraint-Induced Movement Therapy on chronic stroke patients' arm use in activities of daily living: Results of the cluster randomised-controlled HOMECIMT trial” by A. Barzel et al]. Lancet Neurology 14(9), 869-871.

Chuang, L-L., Lin, K-C., Hsu, A-L., Wu, C-Y., Chang, K-C., Li, Y-C., Chen, Y-L. (2015). Reliability and validity of a vertical numerical rating scale supplemented with a faces rating scale in measuring fatigue after stroke. Health and Quality of Life Outcomes,13: 91, 1-9.

Wu, C-Y., Chuang, I-C., Ma, H-I., Lin, K-C., & Chen, C-L. (2016). Validity and responsiveness of the revised nottingham sensation assessment for outcome evaluation in stroke rehabilitation. American Journal of Occupational Therapy, 70(2), 7002290040p1-8.

Li, K-Y., Lin, K-C., Chen, C-K., Liing, R-J., Wu, C-Y., & Chang, W-Y. (2015). Concurrent and predictive validity of arm kinematics with and without trunk restraint during a reaching task in stroke. Archives of Physical Medicine and Rehabilitation, 96(9), 1666-1675.

Lee, Y-Y., Lin, K-C., Wu, C-Y., Liao, C-H., Lin, J-C., Chen, C-L. (2015). Combining afferent stimulation and mirror therapy for improving muscular, sensorimotor, and daily functions after chronic stroke - A randomized, placebo-controlled study. American Journal of Physical Medicine & Rehabilitation, 94(10), 859-868.

Lin, K-C., Wu, Y-F., Chen, I-C., Tsai, P-L., Wu, C-Y., Chen, C-L. (2015). Dual-task performance involving hand dexterity and cognitive tasks and daily functioning in people with schizophrenia: A pilot study. American Journal of Occupational Therapy, 69(3), 6903250020p1-7.

Fan, Y-T., Wu, C-Y., Tsai, W-C., & Lin, K-C. (2015). Effects of lateralized light flash and color on unilateral neglect. Disability and Rehabilitation, 37(26), 2400-2406.

Lai, C-J., Liu, W-Y., Yang, T-F., Chen, C-L., Wu, C-Y., & Chan, A-C. (2015). Pediatric aquatic therapy on motor function and enjoyment in children diagnosed with cerebral palsy of various motor severities. Journal of Child Neurology, 30(2), 200-208.

Li, K-Y., Su, W-J., Fu, H-W., & Pickett, K-A. (2015) Kinesthetic deficit in children with developmental coordination. Research in Developmental Disabilities, 38, 125-133.

Li. K-Y., Fu, H-W., Yau, T-Y., Chen, R-S., & Wu, C-L. (2015) The use of the traditional Chinese version of the University of Pennsylvania Smell Identification test and the smell threshold test for healthy young and old adults in Taiwan. Perceptual and Motor Skills, 120(3), 928-943.

Konczak, J., Aman. J-E., Chen, Y-W., Li, K-Y., & Watson, P.J. (2015) Impaired Limb Proprioception in Adults With Spasmodic Dysphonia. Journal of Voice, 29(6), 777. e17-23.

Huang, Y-Z., Chang, Y-S., Hsu, M-J., Wong, A-M., & Chang, Y-J. (2015) Restoration of central programmed movement pattern by temporal electrical stimulation-assisted training in patients with spinal cerebellar atrophy. Neural Plasticity, 2015:462182.

Chen, C-C., Chuang, Y-F., Yang, H-C., Hsu, M-J., Huang, Y-Z., & Chang, Y-J. (2015) Neuromuscular electrical stimulation of the median nerve facilitates low motor cortex excitability in patients with spinocerebellar ataxia. Journal of Electromyography and Kinesiology, 25(1), 143-150.

Chan, P-Y., Cheng, C-H., & von Leupoldt, A. (2015) The effect of development in respiratory sensory gating measured by electrocortical activations. Neural Plasticity, 2015:389142.

Chan, P-Y., Cheng, C-H., Hsu, S-C., Liu, C-Y., Davenport, P-W., & von Leupoldt, A. (2015) Respiratory sensory gating measured by respiratory-related evoked potentials in generalized anxiety disorder. Frontiers in Psychology, 6, 957.

Cheng, C-H., Baillet, S., & Lin, Y-Y. (2015) Region-specific reduction of auditory sensory gating in older adults. Brain and Cognition, 101, 64-72.

Cheng, C-H., Chan, P-Y., Baillet, S., & Lin, Y-Y. (2015) Age-related reduced somatosensory gating is associated with altered alpha frequency desynchronization. Neural Plasticity, 2015:302878.

Cheng, C-H., Su, H-T., Yen, L-W., Liu, W-Y., & Cheng, H-Y. (2015) Long-term effects of therapeutic Eexercise on nonspecific chronic neck pain: a literature review. Journal of Physical Therapy Science, 27(4), 1271-1276.

Chen, C-Y., Chang, C-W., Lee, S-T., Chen, Y-C., Tang, S-F., Cheng, C-H., & Lin, Y-H. (2015) Is rehabilitation intervention during hospitalization enough for functional improvements in patients undergoing lumbar decompression surgery: a prospective randomized controlled study? Clinical Neurology and Neurosurgery, 129(Suppl 1), S41-46.

Huang, W-P., Wang, C-C., Hung, J-H., Chien, K-C., Liu, W-Y., Cheng, C-H., Ng, H-H., & Lin, Y-H. (2015) Joystick-controlled video console game practices for power wheelchairs indoor driving skills. Journal of Physical Therapy Science, 27(2), 495-498.

Yang, W-C., Cheng, C-H., Wang, H-K., Lin, K-H., & Hsu, W-L. (2015) Mulit-muscle coordination during a challenging stance. European Journal of Applied Physiology, 115(9), 1959-1966.

Hsieh, C-C., & Lin, P-S. (2015) Kinect Tai-Chi exercise for community-dwelling older people: A pilot study. The Journal of Long-Term Care, 19(3), 283-294.

Chen, H-C., Chen, C-L., Kang, L-J., Wu, C-Y., Chen, F-C., Hong, W-H. (2014). Improvement of upper extremity motor control and function after home-based constraint-induced therapy in children with unilateral cerebral palsy: Immediate and long-term effects. Archives of Physical Medicine and Rehabilitation, 95(8), 1423-1432.

Chen, C-L., Lin, K-C., Kang, L-J., Wu, C-Y., Chen, H-C., & Hsieh, Y-W. (2014). Potential predictors of functional outcomes after home-based constraint-induced therapy for children with cerebral palsy. American Journal of Occupational Therapy, 68(2), 159-166.

Chuang, L-L., Wu, C-Y., Lin, K-C., & Hsieh, C-J. (2014). Relative and absolute reliability of a vertical numerical pain rating scale supplemented with a faces pain scale after stroke. Physical Therapy, 94, 129-138.

Hsieh, Y-W., Lin, K-C., Horng, Y-S., Wu, C-Y., Wu, D-J., & Ku, F-L. (2014). Sequential combination of robot-assisted therapy and constraint-induced therapy in stroke rehabilitation: A randomized controlled trial. Journal of Neurology, 261(5), 1037-1045.

Hsieh, Y-W., Lin, K-C., Korivi, M., Lee, T-H., Wu, C-Y., & Wu, K-Y. (2014). The reliability and predictive ability of a biomarker of oxidative DNA damage on functional outcomes after stroke rehabilitation. International Journal of Molecular Sciences, 15(4), 6504-6516.

Hsieh, Y-W., Lin, K-C., Wu, C-Y., Lien, H-Y., Chen, J-L., Chen, C-C., & Chang, W-H. (2014). Predicting clinically significant changes in motor and functional outcomes after robot-assisted stroke rehabilitation. Archives of Physical Medicine and Rehabilitation, 95, 316-321.

Huang, P-C., Hsieh, Y-W., Wang, C-M., Wu, C-Y., Huang, S-C., & Lin, K-C. (2014). Predictors of motor, daily function, and quality of life improvements after upper extremity robot-assisted rehabilitation in stroke. American Journal of Occupational Therapy, 68(3), 325-333.

Lin, K-C., Chen, Y-T., Huang, P-C., Wu, C-Y., Huang. W-L., Yang, H-W., Lai, H-T., & Lu, H-J. (2014). Effect of mirror therapy combined with somatosensory stimulation on motor recovery and daily function in stroke patients: A pilot study. Journal of the Formosan Medical Association, 113(7), 422-428.

Lin, K-C., Huang, P-C., Chen, Y-T., Wu, C-Y., & Huang, W-L. (2014). Combining afferent stimulation and mirror therapy for rehabilitating motor function, motor control, ambulation, and daily functions after stroke. Neurorehabilitation and Neural Repair,28(2), 153-162.

Wu, C-Y., Liing, R-J., Chen, H-C., Chen, C-L., & Lin, K-C. (2014). Arm and trunk movement kinematics during seated reaching within and beyond arm’s length in patients with stroke: A validity study. Physical Therapy,94(6), 845-856.

Cheng, C-H., Cheng, H-Y., Chen, C-P., Lin, K-H., Liu, W-Y., Wang, S-F., Hsu, W-L., & Chuang, Y-F. (2014) Altered co-contraction of cervical muscles in young adults with chronic neck pain during voluntary neck motions. Journal of Physical Therapy Science, 26(4), 587-590.

Chien, A., Lai, D-M., Cheng, C-H., Wang, S-F., Hsu, W-L., & Wang. J-L. (2014) Translation, cross-cultural adaptation, and validation of a Chinese version of the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire. Spine, 39(12), 963-970.

Fang, C-Y., Lee, B-R., & Chang, Y-J. (2014) The supraspinal excitability modulation before rapid and slow goal-directed movements in human. Formosan Journal of Physical Therapy, 39(1), 42-49.

Hsu, W-L., Lin, K-H., Yang, R-S., & Cheng, C-H. (2014) Use of motor abundance in old adults in the regulation of a narrow-based stance. European Journal of applied Physiology, 114(2), 261-271.

Huang, H-H., Ellis, T-D., Wagenaar, R-C., & Fetters, L. (2014) Effect of body-scaled information on reaching in children with hemiplegic cerebral palsy: a pilot study. Pediatric Physical Therapy, 26(1), 28-37.

Huang, H-H., Ragonesi, C-B., Stoner, T., Peffley, T., & Galloway, J-C. (2014) Modified toy cars for mobility and socialization: a case report of a child with cerebral palsy. Pediatric Physical Therapy, 26(1), 76-84.

Li, K-Y., & Wu, Y-H. (2014) Clinical evaluation of motion and position sense in the upper extremities of the elderly using motion analysis system. Clinical Interventions in Aging, 9, 1123-1131.

Lin, M-R., Hwang, H-F., Lin, P-S., & Chen, C-Y. (2014) Relationships of osteoporosis and follow-up length to recurrent falls in older men and women. Osteoporosis International, 25(3), 863-871.

Lin, P-S., Lin, T-C., Chen, C-C., Chi, S-F., Chen, C-K., & Wong, M-K. (2014) An simplified Comprehensive Assessment Tool for long-term care residents in Taiwan. Taiwan Journal of Physical Medicine and Rehabilitation, 42(1), 41-50.

Liu, W-Y., Chen, F-J., Lin, Y-H., Kuo, C-H., Lien, H-Y., & Yu, Y-J.. (2014) Postural alignment in children with bilateral spastic cerebral palsy using a bimanual interface for powered wheelchair control. Journal of Rehabilitation Medicine, 46(1), 39-44.

Logan, S-W., Huang, H-H., Stahlin, K., & Galloway, J-C. (2014) Modified ride-on car use for mobility and socialization: single-case study of an infant with Down syndrome. Pediatric Physical Therapy, 26(4), 418-426.

Li, K-Y., Hsu, W-C., & Lin, L-J. (2014) Effect of the recreational life review program on patients with dementia in an outpatient clinic: a preliminary study. Perceptual and Motor Skills, 119, 1-12.

Chan, P-Y., von Leupoldt, A., Liu, C-Y., & Hsu, S-c. (2014) Respiratory perception measured by cortical neural activations in individuals with generalized anxiety disorder. Respiratory Physiology & Neurobiology, 204, 36-40.

Chenivesse, C., Chan, P-Y., Tsai, H-W., Wheeler-Hegland, K., Silverman, E., von Leupoldt, A., Similowski, T., & Davenport, P. (2014) Negative emotional stimulation decreases respiratory sensory gating in healthy humans. Respiratory Physiology & Neurobiology, 204, 50-57.

Yu, C-H., Hung, Y-C., Lin, Y-H., Chen, G-X., Wei, S-H., Huang, C-H., & Chen, C-S. (2014) A 3D mathematical model to predict spinal joint and hip joint force for trans-tibial amputees with different SACH foot pylon adjustments. Gait & Posture, 40(4), 545-548.

                                                  聯絡窗口: 陳慧雯小姐 amia@mail.cgu.edu.tw

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