中華民國放射線醫學會 辦理一○九年度第三十屆第二次會員大會暨第六十九次學術研討會 (TRS 2020)
日期：2020/09/19　星期六　08:00 ~ 18:00
地點：南港展覽館 1 館 5 樓 (台北市南港區經貿二路 1 號)
主辦單位：中華民國放射線醫學會、馬偕紀念醫院放射線科
【2020】第三十屆第一次會員大會暨第 69 次學術研討會-論文集 (109) 

第 69 次學術研討會壁報展示得獎名單
THE 69TH ANNUAL MEETING OF THE TAIWAN RADIOLOGICAL SOCIETY

特優 EP140-PE 
蔡志謙 (長庚大學健康老化研究中心)

題目：
使用基於fixel分析對於腦性麻痺患者和典型發育兒童白質差異之橫向比較研究
A cross-sectional fixel-based analysis of white matter differences between patients with cerebral palsy and typical development children.

陳耀亮, 陳嘉玲, 蔡志謙, 鄭竹珊, 林嵩翰, 王俊杰
Yao-Liang Chen, Chia-Ling Chen, Chih-Chien Tsai, Jur-Shan Cheng, Sung-Han Lin, Jiun-Jie Wang．

Purpose
The most common etiology for patients with cerebral palsy (CP) was white matter injury by cerebral ischemia in preterm or term infants. In this cross-sectional study, we used fixel-based analysis (FBA) to investigate white matter differences between patients with CP and typical developing (TD) children.

Materials and Methods
From 2011 to 2013, a total of 34 children with CP (Compatible with periventricular　leukomalacia, 19 boys and 15 girls; mean age: 11.5±3.2 years), and 27 sex-balanced TD children (14 boys and 13 girls; mean age: 17.5±3.6 years) were recruited. Diffusion-weighted images were obtained using a 3T MR scanner. Fiber density (FD) and fiber bundle cross-section (FC), the fixel-specific measures, were calculated within each voxel. A Combined measure (termed FDC) was derived by multiplying FD and FC. An FWE-corrected p < 0.05 with a cluster-extent-based threshold of 10 or more voxels was considered statistically significant.

Results
Compared to the TD children, children with CP reduced in FC and FDC in the anterior and posterior part of the corpus callosum, posterior limb of internal capsule,
superior and posterior thalamic radiation, cingulum fiber, optic radiation, and superior longitudinal fasciculus. In contrast, FD reductions were identified in the posterior part of the corpus callosum, posterior thalamic radiation, fornix, and cingulum fiber. Conclusion
This study provides a thorough FBA profile of white matter differences in patients with CP and TD children with new evidence of FD, FC, and FDC, which helped to clarify the influence of disease on the development of specific white matter regions.