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糖尿病與代謝症候群研究團隊

糖尿病與代謝症侯群研究團隊

 

主持人:陳君侃 教授

研究專長:人體生理學、普通生物學

 

研究團隊成員

陳君侃教授、洪麗滿教授、陳冠興醫師

 

研究架構圖:

 

 

 

 

研究計畫:

說明

糖尿病是本世紀人類最重大的疾病之一。對此疾病的瞭解,大多著重於能量代謝異常中,高血糖及高血脂導致的後續影響,包括對心血管、腎臟、神經系統等之負面作用。而對其生化及細胞層面病理機制研究,則著重在細胞成分的糖化及其引發的生物分子功能損傷及發炎反應,脂肪酸與胰島素抗性的形成,氧化壓力的產生及傷害等等。至今對該疾病較有系統及廣泛的代謝變化研究則乃相當缺乏。

 

背景

代謝症候群為多重危險因子之集合,患有代謝症候群者未來罹患心血管疾病之機率為常人的兩倍,罹患第二型糖尿病之機率為五倍。造成代謝症候群之危險因子包括胰島素抗拒性、血脂異常、肥胖、發炎等。至於前述多重危險因子相互間與不同代謝途徑間的交互作用,及其隨病因進展之變異仍多不明。

 

目的

新興的代謝體學(metabolomics)領域定義為探討低分子量代謝物的全譜型及其變異,以呈現生命體因應生理刺激或基因變異所產生的變化,故特別適用於探討如代謝症候群及糖尿病等具有多重危險因子之人類退化性疾病。

 

方法

在本計劃中,利用代謝體分析(metabonomics)的技術,由代謝物構造及其代謝路徑的鑑定,來獲至對糖尿病代謝異常較完整的了解。

 

主要成果

1.   Huang JP, Cheng ML, Wang CH, Shiao MS, Chen JK&Hung LM*. High-fructose and high-fat feeding correspondingly lead to the development of lysoPC-associated apoptotic cardiomyopathy and adrenergic signaling-related cardiac hypertrophy.International Journal of Cardiology 215:65-76, 2016 (IF:4.036 )

2.  Chen KH, Hsu HH, Yang HY, Tian YC, Ko YC, Yang CW, Hung CC. Inhibition of spleen tyrosine kinase (syk) suppresses renal fibrosis through anti-inflammatory effects and down regulation of the MAPK-p38 pathway. Int J Biochem Cell Biol. 2016 May;74:135-44. (IF: 4.046)

3.  Chih-Chun Chang, Keng-Yang Lin, Kang-Yu Peng, Yuan-Ji Day&Hung LM*. Resveratrol exerts anti-obesity in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells.Endocrine Journal63(2) 169-78, 2016(IF:1.997)

4.  Yao J.Y., Liu C.K., Chen K.H., Chen J.K.* The amelioration of metabolic disorders in early stage diabetic rats by resveratrol is associated with mTORC1 regulation. J.Funct. Foods. 18:737-745,2015 (IF:3.574 )

5.  Lou B.S., Wu P.S., Hou C.W., Cheng F.Y., Chen J.K.* Simultaneous quantification of trans-resveratrol and its sulfate and glucuronidemetabolites in rat tissues by stable isotope-dilutionUPLC–MSMS analysis.J. Pharmaceut Biomed. 94:99-105 , 2014 (IF:2.979 )

6.  Lin S.S., Ueng S.W., Niu C.C., Yuan L.J., Yang C.Y., Chen W.J., Lee M. S.,Chen J.K.* Effects of hyperbaric oxygen on the osteogenic differentiation of mesenchymal stem cells. BMC MUSCULOSKEL DIS. 15(56) , 2014 (IF:1.898 )

7.  Hung LM, Huang JP, Liao JM, Yang MH, Li DE, Day YJ, Huang SS. Insulin renders diabetic rats resistant to acute ischemic stroke by arresting nitric oxide reaction with superoxide to form peroxynitrite. Journal of Biomedical Science18 (1): 47, 2014. (IF: 2.736)

8.  Chang CC, Yang MH, Tung HC, Chang CY, TSAI YL, Huang JP, YEN TH &Hung LM*.Resveratrol exhibits differential protective effects on fast- and slow-twitch muscles in streptozotocin-induced diabetic rats. Journal of Diabetes6 (1): 60-7, 2014 (IF:2.349 )

9.  Huang SS, Lu YJ, Huang JP, Wu YT, Day YJ &Hung LM*. The essential role of eNOS activation in insulin-mediated neuroprotection against ischemic stroke in diabetes.Journal of Vascular Surgery59 (2): 483-91, 2014 (IF:2.980 ).

10.  Jing Y.H., Chen K.H., Kuo P.C., Pao C.C., Chen J.K.*Neurodegeneration in streptozotocin-induced diabetic rats is attenuated by treatment with resveratrol. Neuroendocrinology. 98:116-127, 2013 (IF: 4.373 )11.      Chen KH, Hsu HH, Lee CC, Yen TH, Ko YC, Yang CW, Hung CC*. The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts. PLoS One. 2014 Sep 4;9(9):e106554 (IF: 3.234)

12.  Liu YK, Chen KH, Leu YL, Way TD, Wang LW, Chen YJ, Liu YM. Ethanol extracts of CinnamomumkanehiraiHayata leaves induce apoptosis in human hepatoma cell through caspase-3 cascade. Onco Targets Ther. 2014 Dec 31;8:99-109(IF: 2.311)

 

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